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Tuesday, June 28 • 2:30pm - 3:30pm
R Shiny Application for the Evaluation of Surrogacy in Clinical Trials

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Poster #18

In clinical trials, the determination of the true endpoint or the effect of a new therapy on the true endpoint may be difficult, requiring an expensive, invasive or uncomfortable procedure. Furthermore, in some trials the primary endpoint of interest (the “true endpoint”), for example death, is rare and/or takes a long period of time to reach. In such trials, there would be benefit in finding a more proximate endpoint (the “surrogate endpoint”) to determine more quickly the effect of an intervention.

We present a new R Shiny application for the evaluation of surrogate endpoints in randomized clinical trials using patients data. The Shiny application for surrogacy consists of a set of friendly user function which allow the evaluation of different types of endpoints (i.e., continuous, categorical, binary, survival endpoints) and produce a unified and interoperable output. With this new Shiny App, the user does not need to have the R software installed on his computer. It is a web based application. It can also be run from any device with internet connection.

We demonstrate the usage and capacities of this Shiny App for surrogacy using several examples clinical trials in which validation of a surrogate to the primary endpoint in the trials was of interest.

Speakers
TB

Theophile Bigirumurame

Hasselt University


Tuesday June 28, 2016 2:30pm - 3:30pm
Sponsor Pavilion 326 Galvez Street Stanford, CA 94305-6105

Attendees (27)